The ROAR Study: Reactive Oxygen Species and Reproduction
University of California, San Francisco
Summary
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
Eligibility
- Age range
- 18–43 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Female age 18-43 years 2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy. 3. Male partners 18 years of age or older. 4. Must be a registered patient at UCSF Center for Reproductive Health 5. Patient and partner must both be physically present on the day of retreival Exclusion Criteria: 1. Female partner age 44 or older 2. Planning fresh transfer (hybrid PGS cycle) 3. Cleavage stage biopsy 4. Planning to use frozen sperm
Interventions
- Diagnostic TestOxidative stress markers
We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes
Location
- University of California, San FranciscoSan Francisco, California