Basal Ganglia Contributions to Transitions in Freezing of Gait and Parkinson's Disease
University of Minnesota
Summary
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments: Experiment 1: The first experiment will compare LFPs during gait initiation with and without a cue, in people with (PD+FOG) and without FOG (PD-FOG). Experiment 2: The second experiment will compare LFPs during the successful movement transitions vs. freezing-events during a FOG provocation course in people with FOG. Experiment 3: The third experiment will compare LFPs during rapid alternating movements of the wrist and/or foot, in people with and without FOG
Description
The purpose of this research is to examine the underlying pathophysiology and biomarkers of freezing of gait (FOG) and cueing-evoked improvements. This protocol will use the novel (on-label, FDA-approved) local field potential (LFP)-measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease (PD), with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments: Experiment 1: The first experiment will compare LFPs du…
Eligibility
- Age range
- 21–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of idiopathic PD. * Age 21-75 (see Inclusion of Individuals across the Lifespan for justification of age range). * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. * Implanted Medtronic Percept TM Device. * At least 3 months since the initial activation of the neurostimulator. * Undervalued, under-represented, or disenfranchised social group may be included. * Active members of the military (service members), DoD personnel (including civilian employees) may be included. * Individual or group that is disadvantaged…
Interventions
- OtherOFF Parkinson's Medication(s)
Participants will be asked to withhold Parkinson's medications 12 hours prior to their testing visit (if extended-release Parkinson's medications are taken by the participant, they will be asked to withhold these for 24 hours prior to their testing visit).
- OtherOFF Deep Brain Stimulation
Participants will have their deep brain stimulation turned off at the beginning of their testing visit.
Location
- University of Minnesota, Movement Disorders LabMinneapolis, Minnesota