Effects of Ultra Processed Food on Intestinal Energy Harvest
Columbia University
Summary
Ultra processed food is everywhere in modern society and may contain multiple ingredients that affect the way participants' bodies store energy. Some studies have shown that eating a diet high in ultra processed foods leads to weight gain, but these foods have not been studied enough to understand why. Recently, the gut microbiome has become a potential way to measure energy balance in the human body; this is done by measuring how many calories are in the stool. The investigators propose to test a very high ultra-processed food diet where 80% of calories are coming from ultra processed food and a low ultra processed food diet where 20% of the calories are coming from ultra processed food. This study will compare stool sample energy content of the two diets.
Description
This study will recruit people with obesity who are otherwise healthy to participate in this study. Each person will go through baseline testing before starting any of the diets. This consists of one blood draw, one metabolic test which requires each person to remain awake in a small, enclosed room that measures oxygen and carbon dioxide consumption, and one body composition test. Participants will also meet with a study dietitian to review their diet, how to track their diet, and how to collect and ship the stool samples. Each person will be assigned to either 80% or 20% level of ultra proces…
Eligibility
- Age range
- 25+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * BMI 30-40kg/m2 * weight stable * able to download app and willing to use it for duration of study * does own grocery shopping * otherwise healthy Exclusion Criteria: * pregnancy * history of or planned bariatric surgery * history of anti obesity medications
Interventions
- BehavioralDiet containing 80% ultra processed foods
Very high ultra-processed food diet where 80% of calories are coming from ultra processed food
- BehavioralDiet containing 20% ultra processed foods
Low ultra processed food diet where 20% of the calories are coming from ultra processed food
Location
- Columbia University Irving Medical CenterNew York, New York