UAB 2507 - Randomized Phase II Study of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases
University of Alabama at Birmingham
Summary
Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for treatment.
Description
Without a stereotactic frame there is considerable variation in practice in the use of planning target volume (PTV) margins for linac radiosurgery. In particular, the use of a single isocenter for multiple targets geometrically increases the risk that rotational errors will result in significant dosimetric errors, and many centers have considered adding margin. A recent AAPM task group survey has found that \~90% of centers worldwide add a PTV margin to account for error and that 8% add more than 2 mm. The most common margin is 2 mm. Other potential reasons to add a margin include spacial MRI…
Eligibility
- Age range
- 19+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Male or female, aged 19 and older 3. Brain metastases diagnosis not requiring retreatment to the same tumor 4. For females of reproductive potential should undergo pregnancy testing as per UAB Radiation Oncology standard policies 5. Ability of subject or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 1. Current use of cytotoxic chemotherapy within 3 days of treatment. There…
Interventions
- Procedurebrain metastases radiosurgery
Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for treatment.
Location
- University of Alabama at Birmingham (UAB) Hazelrig-Salter Radiation Oncology CenterBirmingham, Alabama