Mechanical and Molecular Determinants of Cartilage Response to Exercise
University of Pittsburgh
Summary
This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.
Description
Participants will be randomly assigned to 1 of 2 treatment groups. Both groups do the same exercise program 3 times a week for 12 weeks on nonconsecutive days. The only difference is that one group will perform the exercises with small resting periods between exercises as normally done in clinical practice. The other group will have two long rests of 45 minutes during the exercise training session. Before and after the exercise programs, participants will undergo a series of assessments including gait analysis, MRI imaging of knees, tests of muscle strength and physical performance. Questionna…
Eligibility
- Age range
- 45–79 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age between 45 and 79 yo. * Clinical diagnosis of primary, early to moderate stage knee osteoarthritis. * BMI range \< 35 kg/m2. * Sedentary lifestyle * Knee joint is the most painful joint in the body. * Ability to speak and understand English. * Willingness to comply with all study procedures and be available for the duration of the study. Exclusion Criteria: * Non-OA disease of the knee. * Advanced knee osteoarthritis * Knee injection in the past 3 months. * Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage asses…
Interventions
- BehavioralExercise with Rest
Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include two 45 minute rest periods between exercises and take about two and a half hours.
- BehavioralExercise without Rest
Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include minimal resting periods between exercises and take about one hour.
Location
- University of PittsburghPittsburgh, Pennsylvania