Interactions Between Delta-9-THC and CBD: A Controlled Human Drug-administration Study Probing a Harm Reduction Strategy
University of California, Los Angeles
Summary
The purpose of this research is to assess the impact of CBD on the effects of THC.
Description
Some evidence indicates that cannabidiol (CBD), a non-intoxicating cannabis component, might mitigate certain effects of THC. This study will examine possible roles for CBD in modulating THC's adverse and analgesic effects.
Eligibility
- Age range
- 21–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Male or non-pregnant and non-lactating females aged 21-55 years * Report cannabis use 1-7 days per week over the month prior to screening * Not currently seeking treatment for their cannabis use * History of inhaled cannabis use * Have a Body Mass Index from 18.5 - 34 kg/m2 * Able to perform all study procedures * Must be using a contraceptive (hormonal or barrier methods) Exclusion Criteria: * Meeting DSM-V criteria for severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, mild or moderate CUD * Evidence of severe psychiatric…
Interventions
- DrugPlacebo
Vaporized Placebo
- DrugTHC
Vaporized THC (20 mg)
- DrugCBD 20 mg
Vaporized CBD (20 mg)
- DrugCBD 40 mg
Vaporized CBD (40 mg)
- DrugCBD 80 mg
Vaporized CBD (80 mg)
Location
- UCLA Center for Cannabis and CannabinoidsLos Angeles, California