High Potency Cannabis: Acute and Protracted Effects
University of California, Los Angeles
Summary
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
Description
This outpatient study will assess the acute pharmacodynamic effects of smoked cannabis with \~50 mg and \~100 mg THC compared to placebo (\~0 mg THC) and whether a brief period of abstinence alters these effects. Metabolism (pharmacokinetics) of THC will be examined to associate behavioral and physiological effects to plasma concentrations of THC and metabolites.
Eligibility
- Age range
- 21–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * • Male or non-pregnant and non-lactating females aged 21-55 years * Report cannabis smoking near daily * Not currently seeking treatment for their cannabis use * Have a Body Mass Index from 18.5 - 34kg/m2. * Able to perform all study procedures * Must be using a contraceptive (hormonal or barrier methods) Exclusion Criteria: * Meeting DSM-V criteria for any substance use disorder other than cannabis, nicotine, caffeine * Do not have positive urine toxicology for cannabis use during screening * Evidence of severe psychiatric illness (e.g. mood or anxiety diso…
Interventions
- DrugPlacebo Comparator: Placebo
Placebo
- DrugLow dose THC
Smoked low dose THC
- DrugHigh dose THC
Smoked high dose THC
Location
- UCLA Center for Cannabis and CannabinoidsLos Angeles, California