Breast Re-irradiation After Second Ipsilateral Lumpectomy (BRASIL Trial)
Youssef Zeidan
Summary
The purpose of this research study is to test the safety and possible harms of treating breast cancer with reirradiation, after breast surgery. The researchers want to find out what effects (good and bad) reirradiation has on people who have already received radiation before surgery.
Eligibility
- Age range
- 40+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosed with ER+HER2- breast cancer * Provision of signed and dated ICF * Stated willingness to comply with all study procedures and availability for the duration of the study * Age ≥ 40 years * Oncotype \< 26 (postmenopausal) \<16 (premenopausal), Low, or Ultra-Low index. * Minimum interval of 18 months from last breast radiotherapy session. * Prior radiation therapy in the form of brachytherapy, external beam MV photons, protons or intraoperative radiation are allowed with an upper total dose limit of 68 Gy (EQD2) for those patients with prior records available. * Ip…
Interventions
- RadiationIntensity modulated radiation therapy (IMRT)
40 Gy total in 15 consecutive weekday sessions to the partial breast
Locations (2)
- Lynn Cancer Institute at Baptist Health, Inc.Boca Raton, Florida
- Miami Cancer Institute at Baptist Health, Inc.Miami, Florida