Lung Cancer Better Breathing Study
Roswell Park Cancer Institute
Summary
This clinical trial evaluates the effects of whether breathing exercises at home can reduce symptoms and help stage I-III lung cancer survivors stay active. Over 70% of lung cancer survivors have trouble breathing, feel tired, and have lower levels of fitness. This is often because their breathing muscles are weaker after surgery. Many survivors find it hard to exercise, which affects their quality of life and overall survival. A training program to strengthen these muscles might reduce breathing problems, lower fatigue, and improve quality of life. Staying active could also help boost the immune system to fight cancer. Respiratory muscle training (RMT) involves a series of breathing and other exercises that are performed to improve the function of the respiratory muscles through resistance and endurance training. Participating in a home-based RMT intervention may reduce symptoms from cancer or treatment in lung cancer survivors.
Description
PRIMARY OBJECTIVES: I. Determine the feasibility of delivering a home-based RMT program to Black and White lung cancer survivors. II. Determine the effects of RMT on symptom management (quality of life \[QoL\], fatigue, dyspnea, sleep, etc.), performance (respiratory muscle and lower extremity strength), and physical activity in Black and White lung cancer survivors. III. Determine if RMT improves cancer related anti-tumor activity (T-cell function) and diminishes markers of immunosuppression (myeloid-derived suppressor cells \[MDSCs\], regulatory T cells) and inflammation (high-sensitivity…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥ 18 years of age. * Able to speak, read and comprehend the English language * Self-identify as non-Hispanic Black or White. * Are \< 24 months of histologically confirmed invasive, non-metastatic, lung cancer diagnosis. * Have received surgical treatment (primarily stage I, II and III) and have completed all cancer treatments (surgery, chemotherapy, radiation). * Willing to provide biospecimen samples for the study (blood) which will be collected in the comfort of the patient's home by a mobile phlebotomy group. * Participant must understand the investigational natu…
Interventions
- ProcedureBiospecimen Collection
Undergo blood sample collection
- OtherElectronic Health Record Review
Ancillary studies
- OtherMedical Device Usage and Evaluation
Use Power Lung breathing device
- OtherQuestionnaire Administration
Ancillary studies
- ProcedureRespiratory Muscle Training
Participate in RMT sessions
- ProcedureSham Intervention
Participate in sham sessions
Location
- Roswell Park Cancer InstituteBuffalo, New York