Fostering Patient-oriented Research in Cardiometabolic Disease Pathogenesis and Prevention
University of Washington
Summary
The goal of this study is to 1) use magnetic resonance imaging (MRI) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious food feeding intervention strategies in children with overweight or obesity.
Eligibility
- Age range
- 9+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Study1: Adult caregiver and Child age 9-11y. Willing to come to in-person focus group * Study 2: Age 9-11y, BMI ≥85th and ≤95th percentile for age and sex * Study 3:Adult caregiver with child who qualify for free or reduced-cost lunch in WA State. Child age 9-11y and with overweight. Exclusion Criteria (study 1 child participants and study 3 criteria for children of adult participants): * Significant health conditions including type 2 diabetes * History of major weight loss or eating disorder * Current use of medications known to alter appetite or body weight (e.g., st…
Interventions
- OtherDiet modification
In Study 2 only, children will be provided all meals for a 7-day period. Meals will consist of nutritious foods, calories provided will exceed the child's estimated daily caloric need, and children will be asked to consume meals ad libitum.
Location
- University of WashingtonSeattle, Washington