University of Pennsylvania
The purpose of this study is to test the accuracy of using RNA in blood as a way to forecast new fracture healing outcome.
This study will follow a registry + biospecimen collection format. Subjects will be enrolled at participating Sites as they present for care for new traumatic appendicular skeletal fractures (0 - ≤7 Days post-injury) and will provide blood specimens for study analysis and future use at up to 4 post-injury windows of treatment (i.e., Window 1, 0 - ≤7 Days; Window 2, 8 - ≤14 days; Window 3, 15 - ≤42 Days; and Window 4, 43 - ≤84 Days post-injury).
Inclusion Criteria: To be eligible to participate in this study, a potential subject must meet ALL of the following criteria: 1. Provision of informed consent for study participation for self in the English language as indicated by a signed and dated, current, and IRB-approved Informed Consent Form (ICF) from 1. patients making their own SOC clinical decisions prior to the time of the 1st blood sample collection, or 2. persons initially unable to make their own SOC clinical decisions, who regain capacity to make clinical care decisions after study blood sample collection during the en…
None. Standard of Care (SOC) only.