UCSF Biobank for Studying Hereditary Cancers and Tumor-Associated Mutations
University of California, San Francisco
Summary
This is a non-therapeutic clinical research biorepository protocol designed to obtain, store, and clinically annotate biospecimens from participants with hereditary cancers. Those biospecimens will be used to generate participant-derived tumor models that will serve as a resource to better understand hereditary cancers and develop new efficient therapies.
Description
Primary Objective: 1. To generate a repository of participant-derived tumor models\* and specimens\*\* - annotated with demographic, clinical, and pathologic data - from adults with solid tumor malignancies with germline or somatic tumor-associated mutations and/or a personal or family history of cancer. * Participant-derived models may include (but are not limited to) xenografts (PDX), organoids (PDO), and cell lines (PDCLs). * Specimens may include tissue, ascites and pleural fluid, and blood. Exploratory Objectives 1. To correlate in vivo drug sensitivity of participant-derived…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: For participants undergoing collection of tissue, ascites, and/or pleural effusions: 1. Ability to understand and willingness to voluntarily sign a written informed consent document prior to any study-related assessments or procedures are conducted. 2. Individuals 18 years of age or older on the day of signing informed consent. 3. Individuals with solid tumor malignancy with germline or somatic cancer-associated mutations and/or Individuals with a family history or personal history of cancer. 4. Must be planning to undergo one of the following procedures as part of their…
Interventions
- ProcedureBlood Sample
Obtained at the time of non-study related routine blood draw.
- ProcedureTissue Sample
Obtained at the time of non-study related routine biopsy or surgical procedure.
- ProcedureExcess fluid Sample
Obtained at the time of non-study related routine biopsy, surgical procedure, paracentesis, or thoracentesis procedure.
- OtherMedical Chart Review
Demographic, clinical, and pathologic information will be extracted from the medical record
Location
- University of California, San FranciscoSan Francisco, California