Baylor Research Institute
This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.
This will be a single arm, multi-center, prospective interventional study. We will approach, consent, and enroll patients referred to the cardiac catheterization laboratory for coronary angiography for the indication of angina without obstructive coronary artery disease (CAD; lesions \<50%, fractional flow reserve (FFR) \>0.80, or non-hyperemic pressure index (RFR) \<0.89). Patients will undergo invasive assessment with CRT first without IC nitrates followed by a dose of 200-500 mcg of intracoronary nitrates and repeat CRT. Approximately 50 patients undergoing coronary angiography for evaluat…
Inclusion Criteria: 1. Aged 18 or older 2. Patient being evaluated for ANOCA or INOCA 3. Clinical suspicion for angina 4. Patient should be able to comply with the protocol. 5. Provide written informed consent before study participation. Exclusion Criteria: 1. Existing coronary artery disease 2. Previous percutaneous interventions within the coronaries 3. Current use (within 48 hours) of long-acting nitrate therapies 4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil) 5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may p…
CRT will be performed in the left and right coronary arteries. Measurements will be obtained in each of the coronaries first without intracoronary nitrates followed by a dose of 200-500 mcg of intracoronary nitrates and repeat measurements.
Arctuva estimate
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