University of Colorado, Boulder
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
The goal of this study is to clarify mechanisms of acute intermittent hypoxia by examining changes in blood biomarkers, neural excitability, and hemoglobin mass. We also aim to clarify how these changes relate to changes in lower limb function in persons with chronic, incomplete spinal cord injury by measuring force steadiness and voluntary muscle activation.
Inclusion Criteria: * 18 to 75 years old (the latter to reduce likelihood of heart disease) * Medically stable with medical clearance from physician to participate * Motor-incomplete spinal cord injuries at or below C2 and at or above L5 * AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.) * More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery * Ability to advance one step overground with or without assistive devices; Exclusion Criteria: * Severe concurrent i…
4 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals
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