Short-Course Antifungal Therapy vs Standard of Care (14 Day Therapy) for Uncomplicated Candidemia (SCAT)

Augusta University

Summary

The goal of this clinical trial is to assess whether a seven-day course of standard of care (echinocandin) antifungal therapy is non-inferior to a 14-day course of echinocandin antifungal therapy in patients with uncomplicated candidemia in terms of clinical, mycologic, adverse events and all cause mortality.

Eligibility

Age range: 18+ years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: 1. Patients ≥ 18 years of age 2. Uncomplicated candidemia (positive blood culture only). No evidence of invasive candidiasis at day 1 or until day 7. 3. Received \< 5 days of prior antifungal therapy 4. Informed Consent for randomization 5. Patients that did not consent to randomization have consented to be used as a natural history (controls) and will allow collection of available data from the medical record. Exclusion Criteria: 1. Inadequate source control (e.g., unable to remove endovascular devices, urinary catheters). 2. Invasive candidiasis of any type (e.g., deep…

Interventions

Drug
Antifungal treatment
Short-course antifungal therapy (7 days) versus standard of care antifungal therapy (14 days)

Location

Augusta University
Augusta, Georgia

Short-Course Antifungal Therapy vs Standard of Care (14 Day Therapy) for Uncomplicated Candidemia (SCAT)

Summary

Eligibility

Interventions

Location

Run this study?

Details

Conditions