Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
University of Florida
Summary
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Description
We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases; * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings; * Age between 18 - 80 years old per the FDA data sheet for PD DBS; * no dementia according to the clinical diagnostic criteria for PD dementia; * ambulatory without the use of walking aids, or another person's assistance. Exclusion Criteria: * other previous neurological surgery; * suspicion of other neurologic…
Interventions
- DeviceDeep Brain Stimulation (DBS)
Patients will receive DBS in the clinically-optimized setting.
Location
- University of FloridaGainesville, Florida