A Cross-Sectional Observational Feasibility Pilot Study in Pediatric Neuroimaging: Quantifying White Matter Microstructural Changes in Adolescents With Multidimensional Assessment of Pubertal Stage
National Institute on Aging (NIA)
Summary
Background: Puberty is a normal part of life. Many big changes occur in all parts of the body as a child matures into an adult. Researchers in this study want to find out more about how the brain changes during puberty. Objective: To study changes that occur in the brain before, during, and after puberty. Eligibility: Healthy children aged 9 to 14 years. Design: Participants will have 2 clinic visits. Each visit will last up to 4 hours. In the first visit, participants will be screened: They will have a physical exam with blood tests. They will complete a mental health questionnaire on a computer. They will undergo a mock magnetic resonance imaging (MRI) scan. Participants will be made comfortable as they lie on the table and slide into the big tube. They will learn what it feels and sounds like to lie still inside a real MRI. At the second visit, participants will have more tests: They will have a physical exam with blood tests. This time the doctor will check for their stage of puberty. The doctor will look at and touch their genitals and breasts. They will have a real MRI exam. An x-ray will be taken of their hand and wrist. This will show how their bones are maturing. They will have a DEXA scan. They will lie on a table while a machine uses x-rays to measure the makeup of their bodies, including bone, muscle, and fat. They will have a 3D body scan. They will wear tight clothes and a shower cap. They will stand on a platform while sensors take pictures of their body.
Description
Study Description: We aim to establish the feasibility of recruitment of children aged 9 to 14 years old to obtain high-quality neuroimaging of white matter determinants employing the Bayesian Monte Carlo analysis of multicomponent driven equilibrium single-component observation of T1 and T2 (BMC-mcDESPOT) and constrained neurite orientation dispersion and density imaging (C-NODDI) Magnetic Resonance Imaging (MRI) techniques with a cross-sectional observational pilot study. We additionally aim to establish the feasibility of multidimensional assessment of pubertal status and body composition…
Eligibility
- Age range
- 9–14 years
- Sex
- All
- Healthy volunteers
- Yes
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study. * Male or female, 9 to 14 years of age. * In good general health * Ability of parent/guardian to understand and the willingness to sign a written informed consent document. * Ability of participant to participate in the assent process and willingness to sign a written informed assent document. EXCLUSION CRITERIA: An individual who meets any of the following…
Location
- National Institute of Aging, Clinical Research UnitBaltimore, Maryland