Image-Based Functionally Adapted Radiation Therapy for Lung Cancer
Sean Fain
Summary
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
Description
Despite the recent implementation of daily adaptation of image-guided radiation treatment using highly precise beam delivery technologies, significant acute and chronic lung toxicity is still reported in approximately 20% of lung cancer patients undergoing radiation therapy. Furthermore, subclinical loss of lung function is a concern for long term outcomes and quality of life. The purpose of this pilot study is to develop, implement and evaluate the efficacy of a new radiation therapy (RT) treatment planning paradigm that incorporates regional pulmonary functional imaging information to reduce…
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial 1. Aged 18-80 years 2. Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.) 3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria Exclusion Criteria: Subjects presenting with…
Interventions
- DrugXenon MRI
MRI with Xenon used for contrast
- Diagnostic TestPulmonary Function Testing
Pulmonary function testing will include spirometry, lung volumes, DLCO and oscillometry
- OtherQuality of Life Questionnaire
European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30+QLQ-LC29)
- OtherMedical Research Council Dyspnea score
modified Medical Research Council Dyspnea score (mMRC Dyspnea)
- OtherSt. George's Respiratory Questionnaire
St. George's Respiratory Questionnaire (SGRQ)
- Diagnostic TestBlood Biomarkers
blood biomarkers of inflammation and injury (e.g. Angiopoetin-2, Interleukin-6, myofibroblast activity, BPD4)
Location
- University of IowaIowa City, Iowa