Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells
Vanderbilt University Medical Center
Summary
The purpose of this study is to understand how cells of the immune system use the common sugar glucose to fuel energy production and as a building block within the cell. Investigators will intravenously infuse a non-radioactive glucose tracer into participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults aged 18 or older Exclusion Criteria: * Pregnant * Prisoner or in police custody * Uncontrolled hyperglycemia/diabetes * Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500cc in an 8 week period * Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, that might interfere with the study objectives * Any reason which, in the opinion of the study investigator, adds additional risk to the participant
Interventions
- Drug13C6-Glucose
Compounded as 5% 13C6-Glucose in sterile water given IV over 2-4 hours as a split bolus and infusion
Location
- Vanderbilt University Medical CenterNashville, Tennessee