Occupational Cancer Screening in Firefighters: A Pilot Study Within the Inova Health System
Inova Health Care Services
Summary
The purpose of this study is to further understand the clinical impact and follow-up steps that may be required based on using whole-body Magnetic Resonance Imaging (MRI) or whole-body ultrasound and blood tests to detect multiple cancers in firefighters. This study involves an investigational test (cancer blood test) that has not been approved by the U.S. Food and Drug Administration (FDA). Whole-body MRI and whole-body ultrasound are approved by the U.S. Food and Drug Administration (FDA) to be used in the diagnosis of some cancers and is approved for adults and children who present other signs of potential disease. In this study, however, the whole-body MRI and the whole-body ultrasound are considered investigational devices because they are not yet approved for use in healthy adults with no other cancer indications.
Description
In July 2022, a Working Group of the International Agency for Research on Cancer (IARC) concluded that occupational work as a firefighter is carcinogenic to humans (Group 1) based on a comprehensive review of the scientific literature. Given the established higher risk of multiple cancer types in firefighters, an emphasis on evaluating and delivering evidence-based preventive health services including screening for early detection of cancer in this population is imperative. Evidence-based recommendations on the optimal screening approach for firefighters at higher risk of cancer and greater un…
Eligibility
- Age range
- 35–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥ 35 years old * at least 10 cumulative years working as a firefighter * Actively serving as a firefighter (active or volunteer) with completion of NFPA physical examination within the past 6 months * Ability to understand and willing to sign informed consent * Ability to understand and willing to sign the Health Insurance Portability and Accountability Act (HIPAA) Authorization * Additional eligibility criteria in protocol Exclusion Criteria: * No prior history of any invasive cancer within the previous 5 years (non-melanoma skin cancer and in situ carcinoma would…
Interventions
- ProcedureWhole Body MRI
Whole body MRI
- ProcedureWhole Body Ultrasound
Whole Body Ultrasound
- DeviceMCD Assay
Cancer detection blood test
- OtherOccupational Exposure Questionnaire
Questionnaire
Location
- Inova Schar Cancer - Saville Cancer Screening and Prevention CenterFairfax, Virginia