Integrating Metabolic and Vascular Sensors to Monitor Cardiometabolic Disorders After Nutrition Interventions
VA Greater Los Angeles Healthcare System
Summary
It is a 12-week study. The participants will follow three different diets, and during each diet period, and the participants will wear our device, and blood samples will be collected.
Description
The investigators will conduct a randomized, controlled crossover intervention study. The investigators will enroll 54 participants, aged \>18 years, BMI \>25 kg/m2 with metabolic syndrome. During the first phase, all participants will consume their habitual diet for 2 weeks to establish baseline. Then participants will be randomized to either a Mediterranean diet (MED), high-fat/low carb diet (HF/LC), or low-fat diet (LF) for 14 days with 2 weeks washout between the different diets. The wearable system will monitor basal levels and the changes for glucose, cholesterol, TG, and NO through swea…
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * United States Veterans * Male or female, age 18-55 years at the time of signing informed consent. * at least 2 of the following: waist circumference \> 40" for men and 35" for women, FBS \>100 mg/dl, triglycerides \> 150 but \< 500 mg/dL, HDL \< 40 mg/dL, Pre- hypertension or hypertension (BP\>120/80 mmHg but \<150/90 mmHg) Exclusion Criteria: * History of diabetes require medications * History of alcohol intake ≥ 20g/day * History of cirrhosis * Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value of \<30 mL/min/1.73 m2 * History of thyroid d…
Interventions
- Dietary SupplementMediterranean diet (MED), high-fat/low carb diet (HF/LC), and low-fat diet (LF)
Participants will be randomized to either Mediterranean diet (MED), high-fat/low carb diet (HF/LC), or low-fat diet (LF).
- DeviceThe integrated sweat sensor and vascular sensor (wearable)
The integrated sweat sensor and vascular sensor will be worn of each diet period.
- Devicecontinuous glucose monitor (CGM)
A continuous glucose monitor (CGM) will be placed on the patients during each diet period.
Location
- Va Greater Los Angeles Healthcare SystemLos Angeles, California