Shared Subcortical Arousal Systems Across Perceptual Modalities
Yale University
Summary
The study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical recording and stimulation, eye metrics and behavioral testing.
Description
The goal of the planned studies is to investigate the role of shared subcortical arousal systems in perception, including visual, auditory and tactile perception. We will investigate shared subcortical arousal circuits in perception using techniques with complementary strengths including fMRI, pupil and eye gaze measurements, behavioral testing, and direct recording and stimulation of the thalamus. Aims 1 and 2 will investigate subcortical arousal systems in visual, auditory and tactile perception using fMRI, pupil and eye gaze measurements and behavioral testing in healthy normal adult parti…