Genicular Artery Embolization for Knee Osteoarthritis: Evaluation of the Correlation Between Subjective Symptom Response and Objective Measures of Inflammation
University of Colorado, Denver
Summary
The goal of this clinical trial is to learn if genicular artery embolization (GAE) can improve knee pain and decrease inflammation in adults with knee osteoarthritis. The main question it aims to answer is: \- Does the GAE procedure improve knee pain and decrease inflammation? Researchers will compare synovial fluid samples taken from the knee before and after the procedure. Participants will: * Have a contrast enhanced MRI before and after the procedure * Complete performance-based measures before and after the procedure * Complete questionnaires before and after the procedure
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥ 18 years * Planned to undergo genicular artery embolization to treat knee osteoarthritis. * Osteoarthritis on knee radiograph (Kellgren-Lawrence score 1-3) within the last 6 months * Persistent moderate to severe knee pain (visual analog scale \[VAS\] \>3) for at least 6 months * Pain refractory or intolerant to conservative therapies (e.g. analgesia, exercise, weight-loss, joint injections, physical therapy) * BMI \< 35 kg / m2 * Stated willingness to comply with study procedures and availability for the duration of the study Exclusion Criteria: * Coagulation di…
Interventions
- ProcedureGAE procedure
Genicular artery embolization
Location
- University of Colorado Anschutz Medical CampusAurora, Colorado