Neural and Psychiatric Consequences of Cannabis Use in Adolescents
University of Miami
Summary
The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.
Eligibility
- Age range
- 14–20 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion criteria at baseline. * Cannabis users: To capture a wide range of cannabis use frequency, meeting DSM-5 criteria for cannabis use disorder will not be required. However, in order to ensure sufficient exposure, we will require majority of adolescents with cannabis use to have a significant cannabis use (self-reported use on more or equal to 10 of the prior 30 days and positive THC urine toxicology). * Depression: Similarly, to capture a wide range of depression illness severity, we will allow participants with subthreshold depression, defined as a raw severity score of \>=30 on the…
Interventions
- BehavioralNeuroimaging Investigation
Participants will undergo fMRI neuroimaging at two timepoints, at the start of the study and at the 1 year follow up. The fMRI is one hour in duration. During the fMRI, participants will complete two tasks investigating diverse aspects of reward circuitry activity. After this is completed, participants will be followed up for another year clinically.
Locations (2)
- University of Miami Clinical Research BuildingMiami, Florida
- Nathan Kline InstituteOrangeburg, New York