Environmental Protection Agency (EPA)
The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm) or clean air for 6.6 hours while at rest. This concentration is the current EPA NAAQS standard for ozone.
Potential health effects of ozone have been extensively studied over decades at various levels of exposure concentration for varying time periods while at varying levels of exertion. The effects of ground level ozone exposure have been well documented, particularly for decrements in lung function and for markers of pulmonary inflammation, such as neutrophils in sputum. (1) The majority of previous studies were done at ozone concentrations between 0.12 and 0.40 ppm, for one to four hours of exposure, with moderate to intermittent exercise to simulate daily activities. These concentrations are c…
Inclusion criteria: * Age 18-35 years old healthy male and female. * No concerning findings on electrocardiogram (ECG) and no history of serious heart arrythmia. * Normal lung function based on current American Thoracic Society(ATS) criteria. * Forced vital capacity (FVC) 80% of that predicted for age, gender and height. * Forced expiratory volume in one second (FEV1) 80% of that predicted for age, gender and height. * FEV1/FVC absolute ratio of at least 70%. * Oxygen saturation normal (94%) at the time of physical exam. Exclusion criteria: * A history of acute or chronic cardiovascu…
6.6 hour exposure to 0.07 ppm ozone while at rest
6.6 hour exposure to clean air (0.00 ppm ozone) while at rest
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