University of Chicago
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.
Administration of oral potassium citrate without oxalate is the next step in determining whether there is a transporter-mediated mechanism linking urinary oxalate and citrate excretion in humans. The study investigators will measure the fractional excretion (FE) of oxalate and citrate. Both substances are freely filtered by the renal glomerulus and are subsequently either secreted or reabsorbed (oxalate), or reabsorbed (citrate). By calculating fractional excretion, the investigators will assess urinary excretion relative to filtered load and tubular handling. Experimental Design: Studies wi…
Inclusion Criteria: Stone formers (SF): * Age 18-70 * History of at least one calcium-based kidney stone Non-stone formers (NSF): * Age 18-70 * No history of kidney stone * 24-hour urine oxalate within laboratory normal range (\<50 mg/day) Exclusion Criteria: History of primarily uric acid, cysteine, or struvite stones History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period…
Consuming a special drink (potassium citrate) during an all-day visit to the University of Chicago research clinic Subjects in both groups will be asked to partake in the same activities, as follows: The day before presenting to the research clinic, subjects will collect urine at home. Subjects will then come to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains potassium citrate. After this, we will collect urine and blood samples throughout the day. While at the clinic, subjects will also receive a boxed lunch at the end of the visit.
Consuming a special drink (potassium citrate) during an all-day visit to the University of Chicago research clinic Subjects in both groups will be asked to partake in the same activities, as follows: The day before presenting to the research clinic, subjects will collect urine at home. Subjects will then come to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains potassium citrate. After this, we will collect urine and blood samples throughout the day. While at the clinic, subjects will also receive a boxed lunch at the end of the visit.
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