A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder
Johns Hopkins University
Summary
The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.
Description
This study is an outpatient, within-subject, randomized controlled trial designed to develop and validate a novel laboratory-based model for assessing resilience in individuals with opioid use disorder (OUD). The study employs a dual-condition design where participants complete two experimental sessions administered in a randomized order: one under a stress condition and under a non-stress condition. In each session, participants will perform a series of standardized laboratory tasks aimed at evaluating cognitive, emotional, and control aspects of resilience. Objective measures (e.g., task per…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Can provide informed consent and can comply with study procedures 2. Adults aged ≥18 years 3. Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment \[remission\]) 4. Urine sample that tests positive for opioids 5. Test negative for pregnancy at screening (females only) Exclusion Criteria: 1. Being pregnant or breastfeeding 2. Significant mental health or physical disorder, or life circumstances, that is judged by…
Interventions
- BehavioralAcute Stress Intervention (MAST-based)
This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
- BehavioralNon-Stress Intervention (NST-based)
In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.
Locations (2)
- Johns Hopkins University Bayview Medical CampusBaltimore, Maryland
- Johns Hopkins University Bayview Medical CampusBaltimore, Maryland