Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (Nat-Geno)
University of Oklahoma
Summary
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prostate cancer. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.
Description
This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC), focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. The study will initially enroll participants…
Eligibility
- Age range
- 18–100 years
- Sex
- Male
- Healthy volunteers
- No
Inclusion Criteria: * Written informed consent signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses. * At least 18 years-of-age at the time of signature of the informed consent form (ICF). * Patients who self-identify as Native American. * Patients with a pathologically proven diagnosis of PC (any stage). * Availability of most recent archived tumor samples. Exclusion Criteria: * Patients not of Native American descent or identity. * Patient does not have archival tissue available.
Interventions
- OtherBio-specimen Collection
Tissue samples will be taken from existing archived collections and sent for further analysis.
- OtherBlood Draw
Blood samples will be collected within the first year of enrollment.
Location
- OU Health Stephenson Cancer CenterOklahoma City, Oklahoma