Precision Neuromodulation in Post-Stroke Aphasia Using TMS
Medical College of Wisconsin
Summary
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).
Description
In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke ap…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosed with left hemisphere stroke * Consent date \>= 1 month after stroke onset * Fluent in English * 18 years of age or older Exclusion Criteria: * Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing * Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease) * A chronic medical condition that is not treated or is unstable * The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e…
Interventions
- DevicePrecision TMS with SFA
Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol
- DeviceControl TMS with SFA
Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.
Location
- Medical College of WisconsinMilwaukee, Wisconsin