Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging
Massachusetts General Hospital
Summary
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 18 or older Additional Inclusion Criteria for Subjects with Epilepsy: * Diagnosed with epilepsy with abnormal interictal EEG Exclusion Criteria: * Contraindications to PET, MRI, or EEG imaging * History of severe brain disease such as stroke and head trauma * History of brain surgery * History of type I or II diabetes mellitus * Fasting plasma glucose level \>200 mg/dL * Employed under direct supervision of the PI conducting the research Additional Exclusion Criteria for Healthy Subjects: * Current use of drugs that modulate brain function * Current or past his…
Interventions
- RadiationFDG-PET/fMRI/EEG imaging
Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.
Location
- Athinoula A. Martinos CenterCharlestown, Massachusetts