A Multicenter, Open-label, Phase 2 Basket Study of MK-5684 in Participants With Selected Solid Tumors (OMAHA-015)

Summary

Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each cancer type in this study. The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  Opevesostat

  Tablet for oral administration.

• Drug
  Fludrocortisone/ Fludrocortisone acetate

  Tablet for oral administration.

• Drug
  Dexamethasone/Dexamethasone acetate

  Tablet for oral administration.

• Drug
  Rescue Medications

  Hydrocortisone or hydrocortisone/hydrocortisone acetate administered via intramuscular injection as rescue medication.

• Drug
  Fulvestrant

  Administered via intramuscular injection.

• Drug
  Exemestane

  Tablet for oral administration.

• Drug

Locations (52)