Predictive Utility and Mechanisms of Sacral Evoked Responses in Sacral Neuromodulation
University of Michigan
Summary
Electrical stimulation of the sacral nerve can help with bladder problems and pelvic pain but researchers don't understand exactly how the stimulation helps. The goal of this study is to examine signals evoked during sacral neuromodulation (SNM or electrical stimulation of the sacral nerve) and their relationship to the selection of stimulation parameters that improve pelvic function symptoms. This study uses SNM parameters based on visual-motor responses (VMR) or sacral evoked responses (SER). It is investigating how the parameter selection impacts change in bladder function.
Description
Some surgical procedures will be conducted at the Chealsea Hospital (75 S Main St, Chelsea, MI 48118) and all others will be done at Michigan Medicine facilities.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Determined by the research team to be fully eligible to receive a sacral neuromodulation implant at a sacral nerve as part of their normal clinical care for overactive bladder (OAB). * Adult (18 or older), capable of providing own informed consent and communicating clearly with research team. * Capable of speaking, reading, and understanding English, as all study questionnaires are standardized assessments only available in English. Exclusion Criteria: * Areflexive or atonic bladder. * Pregnant or planning to become pregnant. If a woman of child-bearing potential wishe…
Interventions
- DeviceSNM based on visual-motor responses (VMRs)
SNM using parameters that elicited the best VMRs in the stage-1 implant procedure
- DeviceSNM based on sacral evoked responses (SERs)
SNM using parameters that elicited the best SERs in the stage-1 implant procedure
Location
- University of MichiganAnn Arbor, Michigan