Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress
Beth Israel Deaconess Medical Center
Summary
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?
Description
To answer these questions, researchers will compare the chemical changes in each participant under progressively higher levels of heat stress, and while taking either vitamin B3 or a placebo. This clinical trial will occur in two stages. Participants may choose participate in stage 1 only, stage 2 only, or both parts of this clinical trial. During stage 1, participants will exercise using a stationary rowing ergometer in a hot and humid environmental chamber for three sessions, each session separated by about a week. * Each session, they will be asked to work out at a progressively higher i…
Eligibility
- Age range
- 18–45 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy volunteer * Any race * Estimated glomerular filtration rate greater than 90 ml/min/1.73m2 * Urine albumin/creatinine ratio less than 30mg/g * Nonsmoker * No regular dietary supplements, particularly vitamin B3 * Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min Exclusion Criteria: * Medical condition preventing safe participation in exercise during heat * Allergy to Vitamin B3 * Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications
Interventions
- Dietary SupplementVitamin B3
1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.
Locations (2)
- Beth Israel Deaconess Medical CenterBoston, Massachusetts
- Boston UniversityBoston, Massachusetts