Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
University of Kansas Medical Center
Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adequate completion of informed consent process with written documentation * Patients 18 - 65 years old * Physician diagnosis of asthma for \> 1 year * Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs. * Blood eosinophil count \> 300 cells/μL and FeNO \>25ppb * Smoking history \<10 pack years * No smoking history (including vapes, cigar, or marijuana use) in the last 3 months * Approved for asthma therapy with either dupilumab, tezepelumab, or benralizumab as part of their standard of care Exclusion Criteria: * Respiratory tract…
Interventions
- Combination ProductHyperpolarized 129 Xenon
Xenon gas contrast agent for MRI
Location
- University of Kansas Medical CenterKansas City, Kansas