Quantifying Differential Individual Responses to OGTT, Starchy Foods, and Mitigators and Its Association With Metabolic Subphenotypes
Stanford University
Summary
This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT). By studying these patterns, the investigators hope to identify different types of metabolism and see if certain foods or food ingredients (like fiber, amino acids, or vinegar) can help control blood sugar better for specific groups. This research will help lay the groundwork for personalized dietary advice based on a person's unique biology.
Description
Participants in the study will be provided with a continuous glucose monitor (CGM) and pre-measured cooked rice to test with different potential mitigators: fiber, acid, amino acid (e.g., leucine), whole protein, and exercise. Each of these conditions will be tested on a different day following strict instructions. For some of these tests, participants will be asked to collect a blood microsample and a saliva sample before and after eating the test meal. A stool sample will be collected at baseline.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * BMI (body mass index) \>19 kg/m2 but \< 45 kg/m2 * HbA1c \< or equal to 7.0% while not on antihyperglycemic medications * Be willing to provide written informed consent for all study procedures. * Able to commute to Stanford campus for on-site visits Exclusion Criteria: * recent (\<6mos) CVD (cardiovascular disease) event * active malignancy * kidney/liver disease * pregnancy/lactation * chronic inflammatory disease * eating disorder * bariatric surgery * history of acute pancreatitis * current use of antihyperglycemic, diabetogenic, or weight loss medications * heavy…
Interventions
- OtherPost prandial testing
A variety of foods, supplements, and short prescriptive exercise will be tested to see which one helps mitigate the rise is postprandial glucose after eating carbohydrate containing foods.
Location
- Stanford UniversityStanford, California