Advancing Troiluzole as a Treatment for Methamphetamine Use Disorder: A Human Laboratory Study
William Stoops
Summary
This will be a human laboratory study evaluating the influence of troriluzole treatment on the effects of methamphetamine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. able to speak/read English, 2. not seeking treatment for drug use at the time of the study, 3. female or male between the ages of 18 and 55 years, 4. recent methamphetamine use verified by methamphetamine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for MUD, 5. judged to be medically and psychiatrically healthy by study physicians other than the diagnosis for MUD (and OUD for the co-morbid MUD and OUD group, see below) at the time of screening, 6. ECG, read by a cardiologist, within normal limits, 7. females using an effective form of birth contro…
Interventions
- DrugPlacebo
The effects of placebo will be determined.
- DrugMethamphetamine
Placebo and methamphetamine will be administered intravenously during experimental sessions.
Location
- Psychopharmacology of Addiction LaboratoryLexington, Kentucky