Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
M.D. Anderson Cancer Center
Summary
The goal of this clinical research study is to learn more about whether individual differences in brain responses to emotional triggers impact rTMS (repetitive transcranial magnetic stimulation) responses in people who smoke.
Description
Primary Objectives: 1. Determine the extent to which neuroaffective individual differences moderate rTMS treatment effects. Our working hypothesis is that smokers characterized by the LPP+ profile will be more likely to reduce nicotine self-administration after inhibitory rTMS to the VMPFC than after excitatory rTMS to the DLPFC. 2. Determine the extent to which neurocognitive individual differences moderate rTMS treatment effects. Our working hypothesis is that smokers characterized by the θ+ profile will be more likely to reduce nicotine self-administration after excitatory rTMS to the DLPF…
Eligibility
- Age range
- 21–60 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 21 to 60 years 2. Report smoking on average, 5 or more cigarettes, little cigars and/or cigarillos per day, within the past 30 days preceding the screening visit. 3. Expired carbon monoxide (CO) ≥ 6ppm and/or test positive for cotinine using a urine cotinine test on day of study visit. 4. Able to follow verbal and written instructions in English and complete all aspects of the study. 5. Have an address and telephone number where they may be reached. 6. Subjects must report current stable residence. Stable residence is a domicile in which an individual can operate as…
Interventions
- ProcedureRepetitive Transcranial Magnetic Stimulation (rTMS)
TMS is a non-invasive procedure in which a coil is placed over the scalp, and focused magnetic pulses are applied to parts of the brain through the coil.
Location
- The University of Texas M. D. Anderson Cancer CenterHouston, Texas