Pharmacological Effects of Cannabidiol on Responses to Stress and Nicotine Withdrawal
Johns Hopkins University
Summary
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.
Description
This study will use a double-blind, placebo-controlled, within-subjects crossover design to examine the effect of acute doses of CBD during exposure to acute stress and nicotine withdrawal using a relevant set of biological and subjective measures that are known to be sensitive to acute stress and to nicotine withdrawal. There will be one in-person medical screening session, 3 pre-laboratory phone sessions, and 3 in-person experimental laboratory sessions separated by at least 72 hrs. Total duration for a study completer is estimated to be 2-3 weeks. Three doses of CBD (0mg, 200mg, and 400mg)…
Eligibility
- Age range
- 21–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Healthy non-treatment seeking adults aged 21-70 (inclusive). 2. Use of \> 5 cigarettes per day for \> 2 years. (Use of other tobacco/nicotine products in addition to cigarettes will be acceptable). 3. Biological confirmation of cigarette use: have an expired carbon monoxide (CO) level \> 8 ppm. 4. Alcohol Use: \< 2 drinks/day on average (\< 14 drinks/week). 5. Sleep schedule: No graveyard or third shift work (i.e., participants must report a normal nighttime sleep schedule). 6. For women of children bearing potential and men with female partners of child-bearing potenti…
Interventions
- DrugEpidiolex
Oral cannabidiol
Location
- Behavioral Pharmacology Research UnitBaltimore, Maryland