Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
Johns Hopkins University
Summary
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
Description
Tissue perfusion is a critical determinant of wound healing, particularly in lower extremity surgery where wound necrosis, dehiscence, and infection can result in limb loss. Despite current advances in wound therapy, rates of wound complications for certain lower extremity incisions remain high. Thus, there remains a critical need to identify agents that may potentially augment wound healing in orthopaedic surgery. Nitropaste has been successfully used in plastic surgery to enhance perfusion and reduce flap necrosis, but its role in orthopaedic surgery is under-explored. In a meta-analysis of…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults aged 18 years or older. * Undergoing surgery for one of the following procedures: * Current Procedural Terminology (CPT) 28415 - Open reduction calcaneal fracture ± internal/external fixation * CPT-27814 - Open reduction of bimalleolar fracture ± internal/external fixation * CPT-27822 - Open reduction trimalleolar ankle fracture, medial and lateral malleoli only, ± internal/external fix * CPT-27823 - Open reduction trimalleolar ankle fracture, including posterior malleolus, ± internal/external fix * CPT-27826 - Open reduction pilon fracture, internal/ex…
Interventions
- DrugNitroglycerin Ointment 2%
Patients will have pre- and post-nitropaste tissue perfusion measurement with the LA-ICG system.
Locations (2)
- The Johns Hopkins HospitalBaltimore, Maryland
- Johns Hopkins Bayview Medical CenterBaltimore, Maryland