Physical Prehabilitation With and Without Creatine/Whey Protein Supplementation Effects on Frailty In Patients With Cirrhosis
University of California, San Francisco
Summary
Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition/exercise prehabilitation app will maintain muscle health in patients with liver disease.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography * Access to digital device and internet at home * Ability to provide written informed consent before any study-related activities * Ability to remain in study for at least 3 months Exclusion Criteria: * Allergy to milk protein * On hemodialysis * No English language proficiency * Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data * Concomitant severe underlying systemic illness tha…
Interventions
- BehavioralHEAL-ME digital app
HEAL-ME is a digital prehabilitation app that provides semi-guided nutrition/exercise prehabilitation
- Dietary SupplementCreatine supplementation
Patients will take 5g creatine supplementation daily for 13 weeks
- Dietary SupplementWhey protein supplementation
Patients will take 35g whey protein supplementation daily
- Dietary SupplementPlacebo
Patients will be administered daily placebo supplementation.
Location
- University of California San FranciscoSan Francisco, California