Radiation Therapy in Reduced Dose and Hypofractionated Schedule After Trans-Oral Robotic Surgery in Intermediate Risk HPV-Mediated Oropharyngeal Squamous Cell Carcinoma

Step 1 Registration: Pre-Operative Eligibility Inclusion Criteria: * Participant aged ≥ 18 years. * Diagnosis of oropharyngeal squamous cell carcinoma. * Eligible to receive transoral robotic surgery. * If status is known, p16 positivity or HPV positivity by in situ hybridization on pathological sampling of lymph node or primary oropharyngeal tumor. If status not known at the time of step-1 registration, otherwise eligible participants may be enrolled and HPV/p16 status must be determined prior to step-2 registration. * Pre-operative TTMV-HPV DNA test collected or is planned to be collected.…