Effects of Fresh Mango as a Sugar Substitute Within High and Low Glycemic Breakfasts on Postprandial Glucose and Insulin
Ball State University
Summary
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.
Description
The investigators will recruit individuals with a BMI in the 18.5-35.0 kg/m2 range from the Ball State University campus and surrounding communities. Each participant will complete four meal trials in a randomized crossover design. At each meal trial, an intravenous catheter will be inserted and baseline blood sample collected. Brachial artery dilation will be measured using prior to the meal. Next, participants will consume one of four breakfast meals in a randomized crossover design: (1) cornflakes with 2% milk + fresh mango, (2) cornflakes with 2% milk + sucrose, (3) steel cut oats with wat…
Eligibility
- Age range
- 18–45 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 18 - 45 years. * Body mass index between 18.5-35.0 kg/m2 * Not pregnant (females only) * Not postmenopausal (females only). * Not been diagnosed with cardiovascular disease. * Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes) * Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease). * Does not regularly take anti-inflammatory drugs (more than 2x week). * Does not use glucose-lowering drugs (e.g., metformin) * Does not use lipid-lowering drugs (e.g., statins) * Does not use tobacco produ…
Interventions
- OtherLow-Glycemic Breakfast Containing Oats and Mango
Low-glycemic breakfast of 80 grams of oats prepared with 473mL water and sweetened with 146 grams of mango.
- OtherHigh-Glycemic Breakfast Containing Cereal and Mango
High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 262 grams of mango.
- OtherLow-Glycemic Breakfast Containing Oats and Table Sugar
Low-glycemic breakfast of 80 grams of oats prepared with 473mL of water and sweetened with 20 grams of table sugar.
- OtherHigh-Glycemic Breakfast Containing Cereal and Table Sugar
High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 36 grams of table sugar.
Location
- Health Professions Building, Ball State UniversityMuncie, Indiana