The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
University of Mississippi Medical Center
Summary
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Criteria for Cohort 1: Healthy Participants Inclusion Criteria: * Adults 18-75 years old * Normal kidney function * No heart failure * BMI 25-30kg/m2 Exclusion Criteria: * Diagnosis of chronic illness * eGFR\<60mL/min/1.73m2 * Pregnancy or breast feeding * History of cutaneous or allergic reaction to iodine-based products of contrast dyes * Hemoglobin levels \<7mg/dL * Acute illness or hospitalization event within 3 months * Unable to stop NSAIDs * Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia,…
Interventions
- OtherHigh protein and sodium meal
Meal with 1g/kg protein content and 3900mg sodium
Location
- University of Mississippi Medical CenterJackson, Mississippi