University of Washington
Preventive genomic medicine, particularly identification of individuals with inherited cancer risk, can improve longevity and quality of life, yet adherence to risk management following cancer genomic testing is poor. The proposed research refines and evaluates two highly scalable population management interventions, web resources and personalized outreach, designed to improve access and use of recommended risk management following cancer genetic testing. Research activities will be conducted in a vertically integrated health system and federally qualified health center and will address post-testing quality and patient safety concerns that are minimizing patient benefit and slowing investments in real world genomic medicine implementation.
Preventive genomic medicine, particularly identification of individuals with inherited cancer risk, provides health systems with the opportunity to improve longevity and quality of life for their patients. The ability to uncover substantially elevated risk of disease through genomic testing, act to reduce that risk, and improve outcomes while lowering costs has been the longstanding promise of genomic medicine. In the case of inherited cancer, however, adherence to recommended risk management following genomic testing is low. Further, our pilot data suggests that health systems are reluctant t…
Inclusion Criteria: * Clinically actionable variant in at least one high penetrance cancer-related gene * Age- and sex- eligible for guideline indicated risk management * Remains eligible for risk management, given personal cancer and surgical history Exclusion Criteria: * Previously opted out of research * Previously opted out of genetic research * On hospice or palliative care * Has advanced dementia or severe cognitive impairment
Mailed educational resources through portal and USPS mail
Phone call to discuss due and overdue screening and other personalized risk management recommendations
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