A Pilot Study of 13Carbon-Based Deep Labeling of Bone Marrow Cells to Map Their Utilization of Extracellular Metabolites

Mayo Clinic

Summary

This study evaluates a novel laboratory method to study how certain bone marrow cells in the body take up nutrients from their environment.

Description

PRIMARY OBJECTIVE: I. Evaluate differences in the amount of extracellular uptake of glucose and amino acids (AAs) between pre-malignant clonal plasma cells (cPCs) and polyclonal plasma cells (pPCs). OUTLINE: This is an observational study. Participants are assigned to 1 of 2 groups. GROUP I: Patients undergo blood collection and bone marrow aspiration as part of their standard care and have their medical records reviewed on study. GROUP II: Healthy volunteers undergo blood collection and bone marrow aspiration on study.

Eligibility

Age range: 18+ years
Sex: All
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria: * All Participants: * At least age 18 years or older * Able to provide informed consent * MGUS Cohort: * International Myeloma Working Group (IMWG) criteria for the diagnosis of non-IgM MGUS Exclusion Criteria: * All Participants: * Unable to provide consent * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) \>1 * Prior history of adverse events with conscious sedation * Ongoing use of immunosuppressive medications * All known pregnant and lactating women will be excluded

Interventions

Other
Non-Interventional Study
Non-interventional study

Location

Mayo Clinic in Rochester
Rochester, Minnesota