Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)
University of Texas at Austin
Summary
Pregnant women with a primary diagnosis of posttraumatic stress disorder (PTSD) (PTSD Checklist for DSM-5 (PCL-5) score \> 33) will be randomized to receive conventional cognitive processing therapy (CPT) (60-min session once/week for 12 weeks) or massed CPT (mCPT) (an intensive schedule of 12 60-min sessions over 5 days, approximately 2-3 sessions per day) via telemedicine, for treatment of PTSD. The research aims will be three-fold: (1) Evaluate the relative efficacy and tolerability of CPT vs. mCPT for treatment of perinatal PTSD and depression; (2) Determine the effect of CPT upon maternal-infant attachment and interaction; (3) Collect pilot data of obstetric and neonatal outcomes among those receiving the two CPT delivery schedules.
Eligibility
- Age range
- 18–46 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Female, ages 18-46, Pregnant (\< 25 weeks), able to read and write in English, History of at least 1 criterion A trauma, Primary diagnosis of PTSD (confirmed by SCID), Psychotropic medications must be stable with no changes ≥ 2 weeks (≥ 6 weeks for fluoxetine), and no medication changes can be made during the course of therapy Exclusion Criteria: * Not currently pregnant, Diagnosis of bipolar disorder, psychotic disorders, Suicidal ideation with plan or intent, Substance use disorder, Regular benzodiazepine use (\> 4x weekly)
Interventions
- BehavioralRegular CPT
Standard-model Cognitive Processing Therapy (CPT) - one 60-min session per week for 12 weeks total
- BehavioralMassed CPT
Massed CPT - two 60-min sessions each day for 5 consecutive days (10 sessions total)
Location
- University of Texas at Austin, Dell Medical School, Department of PsychiatryAustin, Texas