A Double-Blinded Prospective Randomized Clinical Trial Comparing Euploidy Rates Among Embryos Created From Sibling Oocytes Exposed to Sperm After Ultrashort Abstinence Compared With Standard Abstinence
UConn Health
Summary
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.
Description
As part of the in vitro fertilization (IVF) process, eggs are removed from the ovaries and are inseminated (mixed) or injected with sperm. Typically, sperm samples for IVF are produced on the day of egg retrieval. The current recommendation for abstinence prior to providing this sample is 2-7 days. However, new research has shown that there may be improved IVF outcomes with a shorter period of abstinence including improved integrity of sperm DNA (called sperm DNA fragmentation), sperm parameters (such as motility and shape), embryo quality, implantation rates, pregnancy rates, and live birth r…
Eligibility
- Age range
- 18–42 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age. * Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination. * Subjects are utilizing standard insemination or ICSI for fertilization. * Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders). * Subjects are willing to comply with study protocol and procedures and provide written informed consent. Exclusion Criteria: * Subjects are ut…
Interventions
- OtherUltrashort abstinence
Ultrashort abstinence: producing a sperm sample after 1 hour of abstinence.
- OtherStandard abstinence
Standard abstinence: producing a sperm sample after 2-5 days of abstinence.
Location
- The Center for Advanced Reproductive Services, P.C.Farmington, Connecticut