SWOG Cancer Research Network
This research study is for people who have head and neck cancer that has come back or spread to other places in the body.
This study is being done to find out if adding amivantamab hyaluronidase to the usual chemotherapy treatment can improve the usual treatment for advanced head and neck cancers.
Inclusion Criteria: * Participants must have histologically documented squamous cell head and neck carcinoma that meets one of the following criteria; was metastatic at diagnosis, persisted, metastasized or recurred following definitive treatment, or recurred locally and participant has either a contraindication to surgical treatment of lesions (i.e., complete resection is not possible or not expected to be clinically beneficial or resection confers significant functional concerns) or has refused surgical or radiation treatment. Both human papillomavirus (HPV) positive and negative are eligi…
Carboplatin + Paclitaxel + Amivantamab hyaluronidase