Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation
University of California, San Francisco
Summary
This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents. The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD. Participants will: * visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments * have a brain MRI scan before TMS treatments begins and after finishing all TMS * complete questionnaires and report changes in behavior and physical symptoms
Description
This study's primary goal is to examine whether treatment with two forms of transcranial magnetic stimulation (TMS) called theta burst stimulation (TBS) show acceptable tolerability, safety, and preliminary signals of efficacy for adolescents with Obsessive Compulsive Disorder (OCD) that has not responded satisfactorily to 1st line treatments. While TMS is FDA-approved for OCD in adults, data on TMS in youth with OCD is limited. Results will inform on how suitable TMS treatment is for adolescents with OCD, and guide future, larger studies. The study is considered a randomized, single blind, c…
Eligibility
- Age range
- 13–17 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. outpatients 2. ages 13 - 17 years 3. meets current DSM-5 criteria for Obsessive Compulsive Disorder with screening CY-BOCS II score \> 16 (moderate to severe). 4. stable on chronic psychotropic medications and/or therapy for 8 weeks prior to the study and agreeable to continue throughout the study without changes. 5. participants may continue to take medications and record daily usage throughout the study. 6. capacity to provide informed assent and parent or legal guardian able to provide consent. 7. ability to tolerate clinical study procedures. 8. successfully complet…
Interventions
- DeviceDorsal medial Prefrontal Cortex intermittent theta burst stimulation
iTBS stimulation of the dmPFC is a FDA-approved treatment for adults with OCD
- DevicecTBS to ROFC
continuous theta burst stimulation (cTBS) 1,800 pulses per session
Location
- University of California, San FranciscoSan Francisco, California