A PHASE 2, OPEN-LABEL EXTENSION STUDY TO INVESTIGATE THE SAFETY AND EFFICACY OF PF-07868489 ADMINISTERED TO ADULT PARTICIPANTS WITH PULMONARY ARTERIAL HYPERTENSION
Pfizer
Summary
The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
This study is seeking participants who are: * aged 18 years or older at screening of the previous study and completed the required treatment duration with PF-07868469 and other assessments at the end of that study. * willing and able to abide with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. * do not have worsening or hospitalization for worsening PAH during the qualifying study. * not on placement for a surgery to replace any tissue or part of the body (transplant), and planned surgery for PAH. * do not have an ongoing major he…
Interventions
- DrugPF-07868489
Participants will receive subcutaneous doses of PF-07868489 every 4 weeks
Locations (22)
- Heart and Vascular CenterSan Francisco, California
- University of Colorado Anschutz Medical CampusAurora, Colorado
- Clinical Trials Unit at Eastowne Medical Office BuildingChapel Hill, North Carolina
- Pulmonary Specialty Clinic at Eastowne Medical Office BuildingChapel Hill, North Carolina
- Rhode Island HospitalProvidence, Rhode Island
- Center for Advanced Lung CareProvidence, Rhode Island